What is klebsiella bacteremia

In studies from the s to the s, K. Second, a striking clinical finding concerning a new manifestation of community-acquired K.

An unusual invasive presentation of K. In addition, case reports and small series from Korea, Singapore, Japan, India, and Thailand have been published 23 — The Taiwanese patients with K. The third striking clinical observation is the preponderance of K. The proportion of cases of culture-proven bacterial meningitis due to K.

In contrast, in a recent large review only 3 1. These investigators worked in large tertiary-care hospitals or hospitals serving veterans. One of our aims was to delineate in a single time period, with a consistent set of definitions, global differences in the clinical manifestations of serious K.

We also examined the influence of prior antibiotic use on these differences in K. A prospective study of consecutive patients with community-acquired K.

All items on the form were objective criteria, allowing standardization among medical centers. Community-acquired bacteremia was defined as a positive blood culture taken on or within 48 hours of admission.

Severity of acute illness at the time of positive blood cultures was assessed by a previously validated scoring system, based on mental status, vital signs, need for mechanical ventilation, and recent cardiac arrest Pitt bacteremia score Type of infection was defined as pneumonia, urinary tract infection, meningitis, incisional wound infection, other soft tissue infection, intraabdominal infection, and primary bloodstream infection, according to Centers for Disease Control and Prevention definitions In addition, distinctive sites of K.

Liver abscesses were defined by the coexistence of blood cultures positive for K. Meningitis was defined as culture of K. Death was defined as including deaths from all causes within 14 days of the date the first positive blood culture for K. Blood cultures of K. The protocol was reviewed and approved by Institutional Review Boards according to local requirements. Two hundred two The percentage of cases of K. The characteristics of patients with community-acquired K.

The source of bacteremia in community-acquired cases was geographically distinctive Table 2. One South African patient had both pneumonia and meningitis. In four patients, the prior antibiotic was an oxyimino-containing cephalosporin two in South Africa, one in Argentina, and one in Taiwan.

ESBL production was detected in 7 3. None of the patients with community-acquired ESBL-producing strains had recently received an oxyimino-containing cephalosporin. All these seven patients had serious underlying disease and frequent hospitalizations or nursing home admissions, and none had received a quinolone in the 14 days before hospital admission.

Five of seven patients with community-acquired, ciprofloxacin-resistant K. Community-acquired pneumonia due to K. However, no patient with community-acquired K. Of the seven patients with HIV infection and K. The death rates from community-acquired pneumonia due to K. Twenty-five patients had a distinctive syndrome of K. There was no association between liver abscess and gender, age, previous antibiotic use, or presence of underlying liver disease. Patients with any of the distinctive manifestations of K.

When pneumonia due to Klebsiella was first described by Friedlander in , he believed it to be the most common cause of bacterial pneumonia Although this concept was soon refuted in favor of pneumococcus, from the s through the s, 10 to 50 cases of Klebsiella pneumonia were reported each year by large hospitals in the United States 2. In our prospective study, we found only four cases of community-acquired K.

The hospitals surveyed included an inner-city veterans hospital in the United States and two large inner-city public hospitals in Australia. These three centers care for large numbers of indigent and alcoholic patients. Recently published reports from the United States, Israel, and Europe support our observations.

Neither Vergis et al. Nine European studies published since show that only 14 2. In contrast, K. Recent studies from Taiwan, Singapore, and South Africa corroborate these findings.

In a Taiwanese study, K. Alcoholics in Africa and Asia may have limited access to health care perhaps including reduced access to antibiotics compared with those in the Americas, Europe, and Australia, and may have respiratory symptoms later. A weakness of our study is that we were not able to ascertain the duration of symptoms before each patient was hospitalized.

The hypothesis that Klebsiella pneumonia is related to poor primary health care for alcoholics may therefore be less plausible. Bacteremic K. In our study, five cases of bacteremic K. Meningitis caused by K. However, of cases of K. The death rate from bacteremic K. We found only one patient an alcoholic from Taiwan with K. The reason for the geographic preponderance of these severe manifestations of K. The geographic diversity of Klebsiella infections possibly results from interaction between bacterial variables, host variables for example, defects in host defense caused by diabetes mellitus or alcoholism , socioeconomic factors, and possibly genetic susceptibility in different racial groups.

We are studying the phenotypic and genotypic differences in K. Because no more than three hospitals from each country were included in our study, our results may not necessarily be generalizable to hospitals in other regions. It is the most dangerous type of meningitis and can be fatal. Swift treatment with….

Cystitis is an infection of the urinary tract that is caused by bacteria. Anyone can develop cystitis, although it is more common in women. Bacterial pneumonia is an inflammation of the lungs as a result of bacteria.

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What to know about Klebsiella pneumoniae. Medically reviewed by Jill Seladi-Schulman, Ph. Causes Symptoms Treatment Diagnosis Seeing a doctor Contagion Prognosis Summary Klebsiella pneumoniae is a type of bacteria that can cause a range of infections. Share on Pinterest Klebsiella pneumoniae may cause infections such as pneumonia, meningitis, and liver abscess. Pneumonia Meningitis Cellulitis Urinary tract infection cough fever chest pain shortness of breath fever neck stiffness or pain sensitivity to light headaches dizziness confusion delirium irritability nausea vomiting skin redness skin warmth skin swelling skin tenderness fatigue fever painful urination frequent urination pain beneath the pubic bone blood in the urine.

When to see a doctor. Is it contagious? Exposure to air pollutants may amplify risk for depression in healthy individuals. Costs associated with obesity may account for 3. Related Coverage. What are bacteria and what do they do? All about bacterial meningitis.

Medically reviewed by Elaine K. Luo, M. What to know about bacterial pneumonia. Medically reviewed by Stacy Sampson, D. What you need to know about cellulitis. Klebsiella Bacteremia. Arch Intern Med. Coronavirus Resource Center. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue.

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