Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and progesterone.
Your doctor should check your progress on a regular basis every 3 to 6 months to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using estradiol and progesterone. Take the medicine with food as soon as you can, but skip the missed dose if your next dose is due in less than 2 hours. Do not take two doses at one time. Avoid smoking.
It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine. Grapefruit may interact with this medicine and lead to unwanted side effects. Avoid the use of grapefruit products. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with estradiol and progesterone.
This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. You should have a complete physical exam, including blood pressure measurements, breast and pelvic exams, and a Pap test at least yearly.
Follow your doctor's directions for examining your breasts; report any lumps immediately. If you are taking hormone replacement therapy to treat symptoms of menopause, your doctor will check every 3 to 6 months to see if you still need this medication. If you are taking this medication to prevent thinning of the bones osteoporosis , you will take it for a longer period of time.
Before you have any laboratory tests, tell the laboratory personnel that you take hormone replacement therapy, because this medication may interfere with some laboratory tests. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Estrogen and Progestin Hormone Replacement Therapy pronounced as ess' troe jen pro jes' tin. Why is this medication prescribed?
How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names Brand names of combination products Other names. Talk to your doctor about the risks and benefits of taking estrogen and progestin. Other uses for this medicine.
What special precautions should I follow? Before taking hormone replacement therapy, tell your doctor and pharmacist if you are allergic to estrogen, progestin, or any other medications. This is easily done with a simple blood test that will allow your doctor to check any one of the three forms of the hormone. Estrogen testing must be coordinated with a doctor as the interpretation of the results is often misunderstood. Progesterone is a steroid hormone belonging to a class of hormones called progestogens.
It is secreted by the corpus luteum, a temporary endocrine gland that the female body produces after ovulation during the second half of the menstrual cycle. Synthetic steroid hormones with progesterone-like properties are called progestins. Progestin is often combined with estrogen in oral contraceptive pills.
Progesterone is used as a single hormonal contraceptive in the Depoprovera shot and certain intrauterine devices. Progestin is also useful in treating common menopausal symptoms. Progesterone prepares the endometrium the mucous membrane lining the womb for the potential of pregnancy after ovulation.
It triggers the lining to thicken to accept a fertilized egg. It also stops the muscle contractions in the uterus that would cause your body to reject an egg. While the body is producing high levels of progesterone, you will not ovulate. If you do not become pregnant, the corpus luteum breaks down, lowering the progesterone levels in your body. This signals your body to start menstruation. If you do conceive, progesterone continues to stimulate your body to provide the blood vessels in the endometrium that will feed your growing fetus.
Once the placenta develops it begins to secrete progesterone in place of the corpus luteum. This causes the levels to remain elevated throughout the pregnancy, so your body does not produce more eggs.
It also helps prepare the breasts for milk production. In men, progesterone is known as the calming, mood, sleep, libido, and bone-enhancing hormone. Progesterone functions as a precursor in men to produce testosterone while also acting as a balance to decrease estrogen levels.
Synthetic progestins were created to bind to progesterone receptors in the body and create similar effects as progesterone. Progestin can change the lining of the uterus and stop the lining from building up.
Progestin can also be used to treat menopause symptoms such as hot flashes and vaginal dryness. Estrogen can be used alone to treat these symptoms, or it can be combined with progestin.
Women who still have a uterus must use progesterone to counter the effects of estrogen.
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